Patents Assigned to The National University of Singapore (2022)

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10894825

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 6, 2018

    Date of Patent: January 19, 2021

    Assignees: Singapore Health Services PTE LTD, National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • Treatment of fibrosis with interleukin-11 receptor alpha antibody

    Patent number: 10889642

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 21, 2018

    Date of Patent: January 12, 2021

    Assignees: Singapore Health Services PTE LTD, National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • WBP2 AS A CO-PROGNOSTIC FACTOR WITH HER2 FOR STRATIFICATION OF PATIENTS FOR TREATMENT

    Publication number: 20210003574

    Abstract: The present invention provides a method for the prognosis of overall survival, cancer recurrence or response to treatment for a patient suffering from cancer, the method comprising: (a) examining a sample from the patient to determine whether the patient is human epidermal growth factor receptor 2 (HER2) positive or negative; and (b) measuring WW domain-binding protein 2 (WBP2) levels in the patient's sample, wherein a result in step (a) and a result in step (b) provides a prognosis of overall survival, cancer recurrence or response to treatment for the patient. The present invention also provides a kit carrying out the method of the present invention.

    Type: Application

    Filed: June 11, 2020

    Publication date: January 7, 2021

    Applicant: National University of Singapore

    Inventor: Yoon Pin Lim

  • Multi-fluid heat exchanger

    Patent number: 10883767

    Abstract: A multi-fluid heat exchanger (100) includes a primary section (102) and a secondary section (104) arranged contiguous with the primary section (102). The multi-fluid heat exchanger (100) further includes a first heat transfer channel (106) arranged to carry a first fluid (118) and the first heat transfer channel (106) extends between the primary section (102) and the secondary section (104) and carries the first fluid (118) between the sections (102,104). The multi-fluid heat exchanger (100) also includes a second heat transfer channel (108) disposed only at the primary section (102) and arranged to carry a second fluid (114) for heat exchange between the first and second fluids (112,114) at the primary section (102) and a third heat transfer channel (110) disposed only at the secondary section (104) and arranged to carry a third fluid (116) for heat exchange between the first and third fluids (112,116) at the secondary section (104).

    Type: Grant

    Filed: July 5, 2017

    Date of Patent: January 5, 2021

    Assignee: NATIONAL UNIVERSITY OF SINGAPORE

    Inventors: Poh Seng Lee, Chuan Sun

  • Composite hollow fiber membrane

    Patent number: 10882011

    Abstract: There is provided a composite hollow fiber membrane for gas and vapour separation comprising: a porous membrane substrate; and a selective layer of cross-linked polydimethylsiloxane (PDMS) provided on a surface of the porous membrane substrate, wherein the molecular weight of the cross-linked PDMS is ?100 kg/mol. There is also provided a method of forming the composite hollow fiber membrane, and a method of forming the cross-linked polydimethylsiloxane (PDMS) having a molecular weight ?100 kg/mol.

    Type: Grant

    Filed: July 17, 2018

    Date of Patent: January 5, 2021

    Assignee: National University of Singapore

    Inventors: Canzeng Liang, Tai-Shung Chung

  • Methods and Compositions for Modulating TH-GM Cell Function

    Publication number: 20200408757

    Abstract: Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-?-mediated) inflammatory disorders, are also provided.

    Type: Application

    Filed: June 15, 2020

    Publication date: December 31, 2020

    Applicant: National University of Singapore

    Inventors: Xin-yuan FU, Wanqiang SHENG, Yongliang ZHANG, Fan YANG

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10870696

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 6, 2018

    Date of Patent: December 22, 2020

    Assignees: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10870697

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 6, 2018

    Date of Patent: December 22, 2020

    Assignees: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • MULTI-MODE STANDARD CELL LOGIC AND SELF-STARTUP FOR BATTERY-INDIFFERENT OR PURE ENERGY HARVESTING SYSTEMS

    Publication number: 20200395940

    Abstract: A cell logic structure for a battery-indifferent or pure energy harvesting multi-mode system, a battery-indifferent or pure energy harvesting multi-mode system, a method of operating a cell logic structure for a battery-indifferent or pure energy harvesting multi-mode system, and a method of operating battery-indifferent or pure energy harvesting multi-mode system.

    Type: Application

    Filed: February 8, 2019

    Publication date: December 17, 2020

    Applicant: NATIONAL UNIVERSITY OF SINGAPORE

    Inventors: Longyang LIN, Saurabh Jain, Massimo Alioto

  • SPACER DEVICE FOR AN INHALER AND METHOD OF MANUFACTURE THEREOF

    Publication number: 20200390988

    Abstract: A spacer device for an inhaler. The device may include a hollow tube. The device may also include a piston member configured to be inserted into the hollow tube such that a space between a first end of the hollow tube and the piston member may define a chamber for holding a mist released from the inhaler. The piston may be slidable along the hollow tube towards the first end of the hollow tube as the mist is aspirated from the chamber. The hollow tube and the piston member may cooperate to provide a visual indication of the progress of the aspiration of the mist from the chamber.

    Type: Application

    Filed: December 14, 2018

    Publication date: December 17, 2020

    Applicant: NATIONAL UNIVERSITY OF SINGAPORE

    Inventors: Shi Yun Karyn LIM, John ZHENG, Kum Yoong Marcus WOO, Wee Chuan Melvin LOH, Ching Chiuan YEN, Felix AUSTIN, Ulrich Bohannes SCHRAUDOLPH, Hugo VAN BEVER

  • SPIN TORQUE DEVICE

    Publication number: 20200395532

    Abstract: Described is a spin torque device, and a spintronics device Incorporating the spin torque device. The spin torque device comprises a magnetic layer having a switchable magnetisation direction along a first axis, and a spin source layer adapted to generate a spin current from a current Injected along a second axis perpendicular to the first axis. Electrons of different spins in the spin source layer are rearranged by scattering so the spin current is generated in a plane perpendicular to the second axis and polarized at an angle to the first axis, so that the spin current diffuses into the magnetic layer to produce spin torque to switch the magnetisation direction.

    Type: Application

    Filed: May 29, 2020

    Publication date: December 17, 2020

    Applicant: National University of Singapore

    Inventors: Kaiming Cai, Yang Liu, Shuyuan Shi, Hyunsoo Yang

  • DERIVATIVES OF PPD USEFUL FOR COLORING HAIR AND SKIN

    Publication number: 20200390670

    Abstract: The is provided a compound of formula I or II or physiologically acceptable salts or solvates, or oxidised derivatives thereof: where R1 to R3, R13 and R14 are as defined herein. Also disclosed herein are methods of dyeing hair or (temporarily) tattooing the skin using the compounds of formula I or II (or physiologically acceptable salts or solvates, or oxidised derivatives thereof) in a suitable composition.

    Type: Application

    Filed: May 15, 2020

    Publication date: December 17, 2020

    Applicants: National University of Singapore, Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd

    Inventors: Giorgia Pastorin, Paul Bigliardi, Suresh Valiyaveettil, Gopalakrishnan Venkatesan, Arup Sinha, Yuri Herbert Dancik, Mei Bigliardi-Qi

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10865241

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 21, 2018

    Date of Patent: December 15, 2020

    Assignees: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10865240

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 21, 2018

    Date of Patent: December 15, 2020

    Assignees: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • Treatment of fibrosis with interleukin-11 antibody

    Patent number: 10865239

    Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

    Type: Grant

    Filed: August 6, 2018

    Date of Patent: December 15, 2020

    Assignees: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer

  • 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis

    Patent number: 10865384

    Abstract: This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (I) or (II) or a stereoisomer, tautomer, or a salt thereof wherein R1, R2 and R3 independently from another represent hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl; X represents NR4, O or S; and R4 represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl. The method can be used in the late phase of stem cell differentiation and in the compounds of formula (I) or (II) in combination with other small molecules can lead to especially high differentiation of stem cells into cardiomyocytes. The invention further relates to novel compounds which can be used in the method of the invention and kits for stem cell differentiation.

    Type: Grant

    Filed: February 6, 2015

    Date of Patent: December 15, 2020

    Assignees: Agency for Science, Technology and Research, National University of Singapore

    Inventors: Filip Laco, Joo Leng Low, Steve Oh, Christina Li Lin Chai, Qixing Zhong

  • TREATMENT AND PREVENTION OF METABOLIC DISEASES

    Publication number: 20200384083

    Abstract: Methods of treating and preventing metabolic disease through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

    Type: Application

    Filed: May 1, 2020

    Publication date: December 10, 2020

    Applicants: Singapore Health Services PTE LTD., National University of Singapore

    Inventors: Stuart Alexander Cook, Sebastian Schaefer, Brijesh Kumar, Anissa Widjaja

  • METHOD OF REDUCING SEMICONDUCTOR SUBSTRATE SURFACE UNEVENNESS

    Publication number: 20200388501

    Abstract: Disclosed is a method of reducing surface unevenness of a semiconductor wafer (100). In a preferred embodiment, the method comprises: removing a portion of a deposited layer and a protective layer thereon using a first slurry to provide an intermediate surface (1123). In the described embodiment, the deposited layer includes an epitaxial layer (112) and the protective layer includes a first dielectric layer (113). The first slurry includes particles with a hardness level the same as or exceeding that of the epitaxial layer (112). A slurry for use in wafer fabrication for reducing surface unevenness of a semiconductor wafer is also disclosed.

    Type: Application

    Filed: February 19, 2019

    Publication date: December 10, 2020

    Applicants: Massachusetts Institute of Technology, Nanyang Technological University, National University of Singapore

    Inventors: Li Zhang, Kwang Hong Lee, Keith Cheng Yeow Ng, Kenneth Eng Kian Lee, Eugene A. Fitzgerald, Soo Jin Chua, Chuan Seng Tan

  • Continuous-wave terahertz generation via optically pumped rydberg states

    Patent number: 10852620

    Abstract: In example embodiments, a radiation source uses Rydberg states to generate coherent THz radiation (e.g., in the range of 1-20 THz). The radiation source includes a pair of pump lasers (e.g., external-cavity diode lasers (ECDLs)) optically coupled (e.g., by a dichroic mirror and optical fiber) to a heated vapor cell (e.g., a vacuum chamber) holding an atomic species (e.g., rubidium (Rb)). The pump lasers optically pump the atomic species (e.g., Rb) to a predetermined Rydberg state (e.g., the nD5/2 state), which creates a population inversion between that state (e.g., the nD5/2 state) and a lower lying Rydberg state (e.g., the (n+1)P3/2 state). The emission between these two strongly dipole coupled Rydberg states generates coherent THz radiation.

    Type: Grant

    Filed: May 7, 2019

    Date of Patent: December 1, 2020

    Assignee: National University of Singapore

    Inventors: Mun Choong Mark Lam, Sambit Bikas Pal, Wenhui Li, Christian Wolfgang Ernst Gross, Thibault Thomas Vogt

  • Method of forming a multilayer structure for a pixelated display and a multilayer structure for a pixelated display

    Patent number: 10847553

    Abstract: A method of forming a multilayer structure for a pixelated display and a multilayer structure for a pixelated display is provided. The method comprising providing a first wafer comprising first layers disposed over a first substrate, said first layers comprising non-silicon based semiconductor material for forming p-n junction LEDs (light emitting devices); providing a second partially processed wafer comprising silicon-based CMOS (Complementary Metal Oxide Semiconductor) devices formed in second layers disposed over a second substrate, said CMOS devices for controlling the LEDs; and bonding the first and second wafers to form a composite wafer via a double-bonding transfer process.

    Type: Grant

    Filed: January 12, 2018

    Date of Patent: November 24, 2020

    Assignees: Massachusetts Institute of Technology, Nanyang Technological University, National University of Singapore

    Inventors: Li Zhang, Eng Kian Kenneth Lee, Soo Jin Chua, Eugene A. Fitzgerald, Siau Ben Chiah, Joseph Sylvester Chang, Yong Qu, Wei Shu, Kwang Hong Lee, Bing Wang

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